- (+)-FANGCHINOLINE
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- $0.00 / 25KG
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2023-10-16
- CAS:436-77-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- (+)-FANGCHINOLINE
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- $30.00 / 1KG
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2023-09-06
- CAS:436-77-1
- Min. Order: 50KG
- Purity: 99%
- Supply Ability: 500000kg
- Fangchinoline
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- $0.00 / 20mg
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2023-02-24
- CAS:436-77-1
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | (+)-FANGCHINOLINE Basic information |
| Product Name: | (+)-FANGCHINOLINE | | Synonyms: | 6,6',12-TRIMETHOXY-2,2'-DIMETHYLBERBAMAN-7-OL;(+)-FANGCHINOLINE;FANGCHINO-LINE;Fangchinoline,
Demethyltetrandrine;Hanfangichin B;Berbaman-7-ol,6,6',12-trimethoxy-2,2'-dimethyl-, (1β)-;(1S)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol;(1S)-7-Hydroxy-6,6',12-trimethoxy-2,2'-dimethylberbaman | | CAS: | 436-77-1 | | MF: | C37H40N2O6 | | MW: | 608.72 | | EINECS: | | | Product Categories: | reference substance;Alkaloids | | Mol File: | 436-77-1.mol |  |
| | (+)-FANGCHINOLINE Chemical Properties |
| Melting point | 240～242℃ | | Boiling point | 709.7±60.0 °C(Predicted) | | density | 1.204±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | Soluble in chloroform and methanol; | | pka | 9.38±0.20(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | Water Solubility | slightly soluble in water |
| | (+)-FANGCHINOLINE Usage And Synthesis |
| Description | Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days. | | Description | A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook.
f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless
needles. It is strongly laevorotatory with [α]D - 2120 (CHCI3) and has been
shown to be the optical antipode of fanchinoline (q.v.). | | Uses | (+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication. | | Definition | ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S
ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity. | | References | Tomita, Furukawa., Tetrahedron Lett., 4293 (1966) |
| | (+)-FANGCHINOLINE Preparation Products And Raw materials |
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