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| | VU0238441 Basic information |
| Product Name: | VU0238441 | | Synonyms: | VU0238441;1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoroMethyl)phenyl]Methyl]-;7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione;7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione;7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione;mAChR,Inhibitor,VU-0238441,VU0238441,Muscarinic acetylcholine receptor,VU 0238441,inhibit | | CAS: | 85511-68-8 | | MF: | C16H9ClF3NO2 | | MW: | 339.7 | | EINECS: | | | Product Categories: | | | Mol File: | 85511-68-8.mol |  |
| | VU0238441 Chemical Properties |
| Boiling point | 441.7±55.0 °C(Predicted) | | density | 1.500±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: 125 mg/mL (367.97 mM) | | pka | -3?+-.0.20(Predicted) |
| | VU0238441 Usage And Synthesis |
| Biological Activity | VU0238441 is a positive allosteric modulator (PAM) of pan-muscarinic acetylcholine receptor (mAChR) with EC50 values of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and > for M5, M3, M2, M1 and M4, respectively 10 μM. | | in vitro | VU0238441 is an analogue of VU0119498. | | target | | Target | Value | mAChR M5
(Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 2.1 μM mAChR M3
(Cell-free assay) | 2.2 μM | mAChR M2
(Cell-free assay) | 2.8 μM | mAChR M1
(Cell-free assay) | 3.2 μM | mAChR M4
(Cell-free assay) | >10 μM |
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| | VU0238441 Preparation Products And Raw materials |
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