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| Product Name: | N6022 | | Synonyms: | N6022;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022;N6022, >=98%;3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid;N 6022; N-6022;CS-1460;1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]- | | CAS: | 1208315-24-5 | | MF: | C24H22N4O3 | | MW: | 414.46 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 1208315-24-5.mol |  |
| | N6022 Chemical Properties |
| Boiling point | 662.7±55.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | -20° C | | solubility | Soluble in DMSO (up to at least 25 mg/ml). | | pka | 4.63±0.10(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| | N6022 Usage And Synthesis |
| Description | N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3 | | Uses | N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase. | | References | 1) Sun?et al.?(2011),?Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases; ACS Med. Chem. Lett.?2?402
2) Green?et al.?(2012),?Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase; Biochemistry?51?2157
3) Saxena?et al.?(20198),?S-Nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis; Free Radic. Biol. Med.?121?57 |
| | N6022 Preparation Products And Raw materials |
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