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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055 |
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Product Name:2-(o-Tolyloxy)-4H-benzo[d][1,3,2]dioxaphosphinine 2-Oxide
CAS:1222-87-3
Purity:>=95% Package:0.1g;0.25g;1g;5g;10g
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| Company Name: |
Bide Pharmatech Ltd.
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400-1647117 15221909166 |
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product02@bidepharm.com |
| Products Intro: |
Product Name:2-(o-Tolyloxy)-4H-benzo[d][1,3,2]dioxaphosphinine 2-oxide
CAS:1222-87-3
Purity:95% Package:100mg;250mg;1g Remarks:BD61424
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| Company Name: |
Shaanxi Xihua Chemical Industry Co., Ltd
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029-81122149 13992773979 |
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1088@dideu.com |
| Products Intro: |
Product Name:2-(2-METHYLPHENOXY)-4H-1,3,2-BENZODIOXAPHOSPHORIN 2-OXIDE
CAS:1222-87-3
Purity:95% Package:25KG
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| | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Basic information |
| Product Name: | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide | | Synonyms: | 2-(2-cresyl)-4h-1-3-2-benzodioxaphosphorin-2-oxide;2-(o-cresyl)-4h-1,3,2-benzodioxaphoran-2-one;3,2-benzodioxaphosphorin,2-(2-methylphenoxy)-4h-2-oxide;3,2-benzodioxaphosphorin,2-(o-tolyloxy)-4h-2-oxide;cbdp;phosphoricacid,cyclicmethylene-o-phenyleneo-tolylester;o-Tolyl saligenin phosphate;2-(2-METHYLPHENOXY)-4H-1,3,2-BENZODIOXAPHOSPHORIN 2-OXIDE | | CAS: | 1222-87-3 | | MF: | C14H13O4P | | MW: | 276.22 | | EINECS: | | | Product Categories: | | | Mol File: | 1222-87-3.mol |  |
| | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Chemical Properties |
| Boiling point | 362.4±42.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) |
| | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Usage And Synthesis |
| Uses |
Plasma carboxylic-ester hydrolase (EC3.1.1.1) is a very important detoxification route for the toxic stereoisomers of soman. Detoxification is meant in the sense that if soman was bound to carbox-ylic-ester hydrolase, it was not free to inhibit acetylcholinesterase. CBDP (2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide) pretreatment, which inhibited irreversibly carboxylic-ester hydrolase activity without inhibiting phosphoryl phosphatase activity, potentiated the toxicity of soman in mice. In toxicity experiments, CBDP (0.5 mg/kg; iv 1 hr prior to soman) pretreatment potentiated the toxicity of C(±)P(±)-, C(+)P(?)-, and C(?)P(?)-soman to a similar degree[1].
| | References | [1] John G. Clement. “Stereoisomers of soman (pinacolyl methylphosphonofluoridate): Inhibition of serum carboxylic ester hydrolase and potentiation of their toxicity by CBDP (2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin-2-oxide) in mice.” Toxicology and applied pharmacology 89 1 (1987): Pages 141-143. |
| | 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Preparation Products And Raw materials |
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