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| | ISOGUVACINE HYDROCHLORIDE Basic information |
| Product Name: | ISOGUVACINE HYDROCHLORIDE | | Synonyms: | isoguvacine;C13694;1,2,3,6-tetrahydro-4-Pyridinecarboxylic acid;4-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-;ISOGUVACINE HCL;ISOGUVACINE HYDROCHLORIDE;1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBOXYLIC ACIDHYDROCHLORIDE;1,2,3,6-TETRAHYDRO-4-PYRIDINECARBOXYLIC ACID HYDROCHLORIDE | | CAS: | 64603-90-3 | | MF: | C6H9NO2 | | MW: | 127.14 | | EINECS: | | | Product Categories: | GABA/Glycine receptor | | Mol File: | 64603-90-3.mol |  |
| | ISOGUVACINE HYDROCHLORIDE Chemical Properties |
| Melting point | 220 °C | | Boiling point | 280.8±35.0 °C(Predicted) | | density | 1.199±0.06 g/cm3(Predicted) | | RTECS | US5908286 | | storage temp. | Store at RT | | solubility | H2O: refrigerate if not used immediately.soluble | | form | solid | | pka | pK1:9.07 (25°C) | | color | white | | Water Solubility | Soluble in water |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT |
| | ISOGUVACINE HYDROCHLORIDE Usage And Synthesis |
| Description | This base is isolated, together with Guvacine (q.v.) from the nuts of Areca
catechu. It is optically inactive and yields crystalline salts: the hydrochloride,
m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C.
The alkaloid is faintly acid to litmus and on methylation gives the N-methyl
derivative which, on more vigorous methylation yields the dimethyl compound
giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest
that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust,
it yields products with the characteristic pyrrole reaction. | | Chemical Properties | bp 195-197°C | | Uses | A GABAA receptor agonist. Anticonvulsant; antiepileptic. | | Definition | ChEBI: Isoguvacine is a tetrahydropyridine. | | Biological Activity | Specific GABA A receptor agonist. | | References | Jahns., Ber., 21,3404 (1888)
Jahns., ibid, 23, 2972 (1890)
Jahns., ibid, 24,2615 (1891)
Jahns., Arch. Pharrn., 229, 669 (1891)
Trier., Zeit. Physiol. Chern., 85,372 (1913) |
| | ISOGUVACINE HYDROCHLORIDE Preparation Products And Raw materials |
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