| Company Name: |
GL Biochem (Shanghai) Ltd
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| Tel: |
21-61263452 13641803416 |
| Email: |
ymbetter@glbiochem.com |
| Products Intro: |
Product Name:Z-Phe-Tyr-aldehyde
CAS:167498-29-5
Purity:95% HPLC,98% HPLC Package:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
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| Company Name: |
Shanghai Hanhong Scientific Co.,Ltd.
|
| Tel: |
021-54306202 13764082696 |
| Email: |
info@hanhongsci.com |
| Products Intro: |
Product Name:Z-Phe-Tyr-aldehyde
CAS:167498-29-5
Remarks:332P1974
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| | Z-FY-CHO Basic information |
| Product Name: | Z-FY-CHO | | Synonyms: | CATHEPSIN L INHIBITOR II;Z-Phe-Tyr-al;Z-PHE-TYR-CHO;Z-FY-CHO;Z-PHE-TYR-ALDEHYDE;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester;Z-L-PHE-L-TYR-ALDEHYDE;Cathepsin L inhibitor inhibitor | | CAS: | 167498-29-5 | | MF: | C26H26N2O5 | | MW: | 446.49 | | EINECS: | | | Product Categories: | | | Mol File: | 167498-29-5.mol |  |
| | Z-FY-CHO Chemical Properties |
| Boiling point | 726.5±60.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml) | | form | solid | | pka | 9.87±0.15(Predicted) | | color | Off-white to pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| | Z-FY-CHO Usage And Synthesis |
| Description | Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over ?cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic ?pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2 | | Uses | Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease. | | References | 1) Woo et al. (1995), Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L; Bioorg. Med. Chem. Lett., 5 1501
2) Woo et al. (1996), Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo; Eur. J. Pharmacol., 300 131
3) James et al. (2001) Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resoption in vitro; J. Biol. Chem., 276 11507
4) Kaasik et al. (2005), Up regulation if lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium; Eur. J. Neurosci., 22 1023 |
| | Z-FY-CHO Preparation Products And Raw materials |
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