|
|
| | Benaprizine Basic information |
| Product Name: | Benaprizine | | Synonyms: | Benaprizine;Benapryzine;α-Hydroxy-α-phenylbenzeneacetic acid 2-(N-ethyl-N-propylamino)ethyl ester;2-(Ethyl(propyl)amino)ethyl 2-hydroxy-2,2-diphenylacetate;Benaprizine [inn:ban];Unii-14fpc4V3ax;Benzeneacetic acid, α-hydroxy-α-phenyl-, 2-(ethylpropylamino)ethyl ester | | CAS: | 22487-42-9 | | MF: | C21H27NO3 | | MW: | 341.44 | | EINECS: | | | Product Categories: | | | Mol File: | 22487-42-9.mol |  |
| | Benaprizine Chemical Properties |
| | Benaprizine Usage And Synthesis |
| Originator | Brizin,Beecham,UK,1973 | | Uses | Anticholinergic. | | Definition | ChEBI: Benapryzine is a diarylmethane. | | Manufacturing Process | A methanolic solution of sodium methoxide [from sodium (0.2 gram) and dry
methanol (3 ml)] was added dropwise during 20 minutes to a boiling solution
of methyl α,α-diphenylglycollate (11 grams) and 2-ethylpropylaminoethanol (6
grams) in light petroleum (150 ml, BP 80°-100°C) and the methanol that
separated was removed by using a Dean and Starke apparatus. At the end of
5 hours no further separation of methanol occurred and the reaction mixture
after being washed with water (3 x 20 ml) was extracted with 1N hydrochloric
acid (3 x 30 ml).
The acid extracts (after washing with 50 ml ether) were made alkaline with
aqueous 5 N sodium hydroxide solution, the liberated base was extracted into
ether (4 x 50 ml) and the ether extracts were dried (MgSO4). Treatment of
the extracts with hydrogen chloride gave the hydrochloride (11 grams, 70%),
which was obtained as rectangular plates, MP 164° to 166°C, after several
crystallizations from butanone. | | Therapeutic Function | Anticholinergic, Antiparkinsonian |
| | Benaprizine Preparation Products And Raw materials |
|