PDK1 抑制剂
| 中文名称 | PDK1 抑制剂 |
|---|---|
| 中文同义词 | PDK1 抑制剂;PDK1抑制剂(PDK1 INHIBITOR);1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氢-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氢-2-氧代-3-吡啶甲酰胺 |
| 英文名称 | PDK1 inhibitor |
| 英文同义词 | PDK1 inhibitor;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-;4-difluorophenyl)methyl]-N-[(1R)-2-[(2;3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1;2-dihydro-2-oxo-;MP7;PDK1 inhibitor 7 |
| CAS号 | 1001409-50-2 |
| 分子式 | C28H22F2N4O4 |
| 分子量 | 516.5 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1001409-50-2.mol |
| 结构式 |  |
PDK1 抑制剂 性质
| 沸点 | 724.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.398 |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 11.48±0.20(Predicted) |
PDK1
Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC 50 values in the micromolar range.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-14440 | PDK1 抑制剂 MP7 | 1001409-50-2 | 5mg | 1300元 |
| 2024/04/30 | HY-14440 | PDK1 抑制剂 MP7 | 1001409-50-2 | 10mg | 2100元 |