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| Product Name: | DFMO | | Synonyms: | 96020-91-6 (Mono-hydrochloride, monohydrate);alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid;Brn 2250529;Ccris 3295;DL-2-(Difluoromethyl)-ornithinehydrochloride;DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate;DIFLUOROMETHYLORNITHINE(RG);α-Difluoromethyl-DL-ornithine | | CAS: | 70052-12-9 | | MF: | C6H12F2N2O2 | | MW: | 182.17 | | EINECS: | | | Product Categories: | facial hair remover | | Mol File: | 70052-12-9.mol |  |
| Melting point | 138 °C | | Boiling point | 347.0±42.0 °C(Predicted) | | density | 1.1800 (estimate) | | storage temp. | Store at 0°C | | solubility | H2O: >10 mg/mL, soluble | | pka | 1.22±0.44(Predicted) | | form | solid | | color | white |
| Chemical Properties | Off-white powder | | Uses | DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line. | | Definition | ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine. | | General Description | Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues. | | Biological Activity | Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. | | Biochem/physiol Actions | Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. |
| | DFMO Preparation Products And Raw materials |
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