- Nicaraven
-
- $1.00 / 1ASSAYS
-
2019-09-06
- CAS:79455-30-4
- Min. Order: 1ASSAYS
- Purity: 95%~99%
- Supply Ability: per week:100kg
|
| | Nicaraven Basic information |
| Product Name: | Nicaraven | | Synonyms: | n,n'-propylenedinicotinamide;NICARAVEN;1,2-bis(nicotinamido)propane;AVS;N,N'-(1-Methylethylene)bis(pyridine-3-carboxamide);N,N'-(1-Methylethylene)bisnicotinamide;N,N'-Propylenebis(nicotinamide);N,N'-Propylenebisnicotinamide | | CAS: | 79455-30-4 | | MF: | C15H16N4O2 | | MW: | 284.31 | | EINECS: | 1806241-263-5 | | Product Categories: | Inhibitors | | Mol File: | 79455-30-4.mol |  |
| | Nicaraven Chemical Properties |
| Melting point | 156-157° | | Boiling point | 635.9±40.0 °C(Predicted) | | density | 1.213±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml | | form | A crystalline solid | | pka | 12.93±0.46(Predicted) |
| | Nicaraven Usage And Synthesis |
| Description | Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury. |
| | Nicaraven Preparation Products And Raw materials |
|