| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:PB 28 dihydrochloride;1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-Methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride
CAS:172906-90-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:PB 28 dihydrochloride
CAS:172906-90-0
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | PB28dihydrochloride Basic information |
| Product Name: | PB28dihydrochloride | | Synonyms: | 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride;PB-28;Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-;PB28 dihydrochloride >=98% (HPLC), solid | | CAS: | 172906-90-0 | | MF: | C24H38N2O | | MW: | 370.57 | | EINECS: | | | Product Categories: | | | Mol File: | 172906-90-0.mol |  |
| | PB28dihydrochloride Chemical Properties |
| Boiling point | 501.4±50.0 °C(Predicted) | | density | 1.032±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | H2O: ~10mg/mL at 60°C | | pka | 8.32±0.70(Predicted) | | form | solid | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | PB28dihydrochloride Usage And Synthesis |
| Uses | PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent. | | Definition | ChEBI: PB28 is a member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (sigma2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. It has a role as an anticoronaviral agent, an antineoplastic agent, an apoptosis inducer and a sigma-2 receptor agonist. It is an aromatic ether, a member of piperazines and a member of tetralins. | | Biological Activity | High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells. |
| | PB28dihydrochloride Preparation Products And Raw materials |
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