| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PF-622
CAS:898235-65-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:PF-622
CAS:898235-65-9
Purity:98% Package:50mg; 5mg; 10mg Remarks:Medbio
|
| Company Name: |
ApexBio Technology
|
| Tel: |
+ 1-832-696-8203 |
| Email: |
sales@apexbt.com |
| Products Intro: |
Product Name:PF-622
CAS:898235-65-9
|
|
| Product Name: | PF-622 | | Synonyms: | PF-622;N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide;FAAH Inhibitor, PF-622;1-Piperazinecarboxamide, N-phenyl-4-(2-quinolinylmethyl)- | | CAS: | 898235-65-9 | | MF: | C21H22N4O | | MW: | 346.43 | | EINECS: | | | Product Categories: | | | Mol File: | 898235-65-9.mol |  |
| | PF-622 Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml). | | form | Off-white solid. | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | PF-622 Usage And Synthesis |
| Description | PF-622 (898235-65-9) is a potent and selective irreversible FAAH inhibitor. Covalently modifies active site-serine (IC50=33 nM). Completely selective for FAAH relative to other mammalian serine hydrolases. Cell permeable | | in vitro | pf-622 inhibited the activity of faah in a time-dependent manner with the ic50 values of 0.99 and 0.033 μm in human recombinant faah for 5 and 60 minutes, respectively [1]. in various human and murine tissue proteome samples, pf-622 showed highly selectivity for faah in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μm [1]. pf-622 at 1 μm decreased il-2 production in both healthy subjects and in hcv patients [2]. | | References | 1) Ahn et al. (2007), Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity; Biochemistry, 46 13019 |
| | PF-622 Preparation Products And Raw materials |
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