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| | HEMATOPORPHYRIN DIHYDROCHLORIDE Basic information |
| Product Name: | HEMATOPORPHYRIN DIHYDROCHLORIDE | | Synonyms: | 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRIN IX DIHYDROCHLORIDE;HEMATOPORPHYRIN DIHYDROCHLORIDE;HAEMATOPORPHYRIN DIHYDROCHLORIDE | | CAS: | 17696-69-4 | | MF: | C34H39ClN4O6 | | MW: | 635.16 | | EINECS: | 241-699-4 | | Product Categories: | Natural Porphyrins and Derivitives;Porphyrins;Biochemistry;Miscellaneous Biochemicals;porphine (porphyrin) ligand | | Mol File: | 17696-69-4.mol |  |
| | HEMATOPORPHYRIN DIHYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Very Dark Red | | Water Solubility | Insoluble in water. Soluble in pyridine (5%). | | Merck | 14,4636 | | BRN | 78957 | | Stability: | Hygroscopic | | EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
| Risk Statements | 33 | | RTECS | TS5505000 | | TSCA | Yes | | Toxicity | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
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ALFA
| English |
| | HEMATOPORPHYRIN DIHYDROCHLORIDE Usage And Synthesis |
| Description | Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation. | | Uses | Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate. |
| | HEMATOPORPHYRIN DIHYDROCHLORIDE Preparation Products And Raw materials |
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