(4E)-TCO-PEG4-NHS ESTER
| 中文名称 | (4E)-TCO-PEG4-NHS ESTER |
|---|---|
| 中文同义词 | (4E)-反式环辛烯-四聚乙二醇-NHS 酯;(4E)-反式环辛烯-四聚乙二醇-琥珀酰亚胺酯;2,5-二氧代吡咯烷-1-基 1-(环辛-4-烯-1-基氧基)-1-氧代-5,8,11,14-四氧杂-2-氮杂十七烷-17-酸酯 |
| 英文名称 | TCO-PEG4-NHS ester |
| 英文同义词 | TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate |
| CAS号 | 1613439-69-2 |
| 分子式 | C24H38N2O10 |
| 分子量 | 514.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1613439-69-2.mol |
| 结构式 |  |
(4E)-TCO-PEG4-NHS ESTER 性质
| 密度 | 1.23±0.1 g/cm3(Predicted) |
|---|---|
| 溶解度 | 溶于DMSO、DCM、DMF |
| 酸度系数(pKa) | 11.95±0.46(Predicted) |
| InChI | InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- |
| InChIKey | ZKPMRASGLDBKPF-UPHRSURJSA-N |
| SMILES | C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
TCO-PEG4-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类。TCO-PEG4-NHS ester 可用于合成一系列 PROTAC 分子。TCO-PEG4-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Cleavable
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PEGs
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.