罗红霉素钙盐(链霉菌属载体)
| 中文名称 | 罗红霉素钙盐(链霉菌属载体) |
|---|---|
| 中文同义词 | IONOMYCIN CAICIUM SALT 钙盐;钙离子霉素;罗红霉素钙盐;罗红霉素(游离酸);罗红霉素钙盐(链霉菌属载体);IONOMYCIN CALCIUM SALT 钙离子霉素;离子霉素钙盐;链霉菌属载体 |
| 英文名称 | IONOMYCIN CALCIUM SALT |
| 英文同义词 | IONOMYCIN CALCIUM SALT;IONOMYCIN, CALCIUM SALT, STREPTOMYCES CONGLOBATUS;IONOMYCIN CA-SALT;ionomycin calcium;10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-(2S,2R,5S,5S)-octahydro-5-(1R)-1-hydroxyethyl-2,5-dimethyl2,2-bifuran-5-yl-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-;Calcium ionomycin.;Ionomycin Ca2+ Salt;Ionomycin Ca2+ salt |
| CAS号 | 56092-82-1 |
| 分子式 | C41H70CaO9 |
| 分子量 | 747.07 |
| EINECS号 | 617-954-4 |
| 相关类别 | 合成;化工原料;生化试剂;试剂盒-细胞分析试剂盒;小分子;Ion Channels;antibiotic;Antibiotic Ready Made SolutionsResearch Essentials;Antibiotics;Antibiotics A to;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Miscellaneous |
| Mol文件 | 56092-82-1.mol |
| 结构式 |  |
罗红霉素钙盐(链霉菌属载体) 性质
| 熔点 | 205-206 C |
|---|---|
| 闪点 | 87 °C |
| 储存条件 | −20°C |
| 溶解度 | 溶于 DMSO (10mg/ml)。也溶于乙醇或甲醇 |
| 形态 | 白色至类白色固体 |
| 颜色 | 白色至类白色 |
| 敏感性 | Light Sensitive |
| BRN | 1416163 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
Calcium ionophore
Ionomycin is a Calcium ionophore and an antibiotic produced by
Streptomyces conglobatus
.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca
2+
concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | XW560928211 | 钙离子霉素 | 56092-82-1 | 5MG | 1970元 |
| 2024/04/30 | HY-13434A | 罗红霉素钙盐(链霉菌属载体) Ionomycin calcium | 56092-82-1 | 1 mg | 2380元 |