α-甘露糖苷酶I抑制剂，1-Deoxymannojirimycin hydrochloride 是一种选择性的 I 类 α1,2-甘露糖苷酶 (class I α1,2-mannosidase) 抑制剂，IC50 为 20 μM。1-Deoxymannojirimycin hydrochloride 也是一种 N-联糖基化 (N-linked glycosylation) 抑制剂，可抑制 HIV-1 毒株，具有抗病毒活性。
中文名称
1-Deoxymannojirimycin hydrochloride
中文别名
1-甘露糖野尻霉素盐酸盐;去氧麦诺吉利霉素盐酸盐;(2R,3R,4R,5R)-2-(羟甲基)-3,4,5-***三醇盐酸盐;1-脱氧麦诺吉利霉素
英文名称
1-Deoxymannojirimycin hydrochloride
英文别名
3,4,5-Piperidinetriol,2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5R)-;Deoxymannojirimycin Hydrochloride;1-Deoxymannojirimycin hydrochloride;(+)-1-Deoxynojirimycin hydrochloride;manno-1-Deoxynojirimycin hydrochloride
Cas No.
73465-43-7
分子式
C6H13NO4.HCl
分子量
199.63
包装储存
4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
生物活性
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity.
性状
Solid
IC50 & Target[1][2]
IC50: 20 μM (α1,2-mannosidase I)
N-linked glycosylation
HIV‐1
运输条件
Room temperature or refrigerated transportation.
储存方式
4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
结构分类
Alkaloids
Piperidine Alkaloids
来源
Plants
other families
参考文献
[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [Information]
[2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. [Information]
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