ChemicalBook CAS DataBase List 2-Chloro-4-nitroaniline

2-Chloro-4-nitroaniline synthesis

10synthesis methods

Product Name:2-Chloro-4-nitroaniline
CAS Number:121-87-9
Molecular formula:C6H5ClN2O2
Molecular Weight:172.57

99-54-7 Synthesis

99-54-7
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$13.00/25g

121-87-9
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$35.79/250g

Yield:121-87-9 99.45%

Reaction Conditions:

with ammonium hydroxide;tetrabutylammomium bromide;copper(l) chloride in water at 140; under 24002.4 Torr;Reagent/catalyst;Temperature;Pressure;

Steps:

1.c; 2.c; 3.c; 1.c; 2.c; 3.c; 4.c; 5-10
(c) Aminolysis reaction: add 150g of high-purity 3,4-dichloronitrobenzene prepared in step to 200g of water, addCuprous chloride 1.5g, tetrabutyl bromide press 3.5g, lead to the recovery of 65g of the previous batch of ammonia, then add 60g of liquid ammonia, and raise the temperature to 140C, the pressure is 3.2 MPa, the heat preservation reaction is to the end, cooling and washing, to obtain 134 g of o-chloro-p-nitroaniline, purity 99.2%.

References:

Zhejiang Runtu Institute Co., Ltd.;Gu Gaowei;Chen Baoxing;Gao Lijiang;Huang Zhong CN111039798, 2020, A Location in patent:Paragraph 0040; 0043; 0046; 0049; 0051; 0054; 0056; 0059

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