4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine synthesis
- Product Name:4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine
- CAS Number:89392-03-0
- Molecular formula:C13H13N3O4
- Molecular Weight:275.26
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Yield: 83%
Reaction Conditions:
with triethylamine in acetonitrile at 60; for 6 h;Green chemistry;
Steps:
Step-4: Preparation of phenyl 4,6-dimethoxypyrimidin-2-ylcarbamate (6):
To a stirred solution of compound 5 (1 g, 6.45 mmol) in acetonitrile (10 mL) was added triethylamine (0.85 g, 8.40 mmol) followed by phenyl chloroformate (1.31 g, 8.37 mmol) at room temperature. The reaction mixture was heated to 60 °C for 6 h. The reaction mixture was cooled to room temperature and diluted with water (6 mL) and the precipitated solids were filtered and dried under vacuum to obtain compound 6. White solid, Yield: 1.48 g, 83 %; m.p.: 119 °C; 1H NMR (400 MHz, DMSO-d6): δ 7.65 (s, 1H), 7.42-7.40 (m, 2H), 7.18-7.14 (m, 3H), 5.80 (s, 1H), 3.96 (s, 6H); ESI-MS: m/z, 276.1 (M+1).
References:
Gilbile, Rohidas;Bhavani, Ram;Vyas, Ritu [Asian Journal of Chemistry,2017,vol. 29,# 7,p. 1477 - 1481]
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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4 suppliers
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108-95-2
717 suppliers
$14.00/25g
89392-03-0
202 suppliers
$6.00/10g