ChemicalBook CAS DataBase List 6-Quinazolinol, 4-chloro-7-methoxy-

6-Quinazolinol, 4-chloro-7-methoxy- synthesis

14synthesis methods

Product Name:6-Quinazolinol, 4-chloro-7-methoxy-
CAS Number:574745-97-4
Molecular formula:C9H7ClN2O2
Molecular Weight:210.62

230955-75-6 Synthesis

230955-75-6
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$11.00/250mg

574745-97-4
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$45.00/1g

Yield: 94%

Reaction Conditions:

with ammonia in methanol at 20; for 1.5 h;

Steps:

10.4
A suspension of 4-chloro-7-methoxyquinazolin-6-yl acetate (prepared as described in Example 25-5 of WO01/66099, 10.1 g, 40 mmol) in 6N methanolic ammonia (200 ml) was stirred at room temperature for 90 minutes. The solvents were evaporated under vacuum. Water was added and the resulting suspension was filtered. The solid obtained was washed with water, ether and dried under high. vacuum in the presence-of phosphorus pentoxide to GIVE 4-CHLORO-7-METHOXYQUINAZOLIN-6-OL (7.9 G, 94%). NMR SPECTRUM: (DMSOD6) 4.02 (S, 3H), 7.40 (s, 1H), 7.43 (s, 1H), 8. 81 (s, 1H).

References:

ASTRAZENECA AB;ASTRAZENECA UK LIMITED WO2005/26151, 2005, A1 Location in patent:Page/Page column 124

179688-53-0 Synthesis