ChemicalBook CAS DataBase List Phenol, 3-(4-chloro-2-quinazolinyl)-, 1-acetate

Phenol, 3-(4-chloro-2-quinazolinyl)-, 1-acetate synthesis

6synthesis methods

Product Name:Phenol, 3-(4-chloro-2-quinazolinyl)-, 1-acetate
CAS Number:911417-24-8
Molecular formula:C16H11ClN2O2
Molecular Weight:298.72

371947-93-2 Synthesis

3-(4-Oxo-3,4-dihydroquinazolin-2-yl)phenyl acetate

371947-93-2
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Phenol, 3-(4-chloro-2-quinazolinyl)-, 1-acetate

911417-24-8
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Yield:911417-24-8 100%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide for 4 h;Heating / reflux;

Steps:

5

To 3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl acetate was added thionyl chloride (100 mL) and DMF (2 mL) and the reaction was heated to reflux for 4 h. The flask was allowed to cool to RT and then concentrated in vacuo. The crude product was azeotroped with toluene (2 X 50 mL), taken up in CH₂Cl₂ (300 mL) and washed with saturated NaHCO₃ (3 X 50 mL), water (1 X 50 mL) and brine (1 X 50 mL), dried with MgSO₄ and concentrated in vacuo to give 3-(4-chloroquinazolin-2-yl)phenyl acetate. (9.77 g, mmol, 100%).

References:

WO2008/54599,2008,A2 Location in patent:Page/Page column 106

330657-87-9 Synthesis

BenzaMide, N-[2-(aMinocarbonyl)phenyl]-3-Methoxy-

330657-87-9
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911417-24-8
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References

1711-05-3
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$8.00/1g

911417-24-8
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Benzenecarboximidic acid, 2-amino- (9CI)

28144-70-9
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911417-24-8
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References

4(3H)-Quinazolinone, 2-(3-Methoxyphenyl)-

56071-04-6
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911417-24-8
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References