| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
PBS (pH 7.2): 10 mg/ml
Water: Soluble | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
2-Methylthioadenosine Tiphosphate Tetrasodium Salt is a potent P2-purinoceptor agonist affecting cell proliferation and apoptosis, and cytokine secretion. Also mediates the relaxation of gut smooth muscle. | [storage]
Store at -20°C | [References]
[1] ERIC POLLATZEK . Functional expression of P2 purinoceptors in a primary neuroglial cell culture of the rat arcuate nucleus[J]. Neuroscience, 2016, 327: Pages 95-114. DOI: 10.1016/j.neuroscience.2016.04.009
[2] JOEL B SCHACHTER T K H. An examination of deoxyadenosine 5′(α-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor[J]. British Journal of Pharmacology, 2009, 121 2: 338-344. DOI: 10.1038/sj.bjp.0701136
[3] S J PARKINSON S A W S L Carrithers. Opposing adenine nucleotide-dependent pathways regulate guanylyl cyclase C in rat intestine.[J]. The Journal of Biological Chemistry, 1994, 269 36: 22683-22690.
[4] CINDY ZENG. Synergistic Effect of Uroguanylin and D1 Dopamine Receptors on Sodium Excretion in Hypertension[J]. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022, 26 1. DOI: 10.1161/jaha.121.022827 |
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