| Identification | Back Directory | [Name]
2 MeS AMP bis-sodium | [CAS]
81921-45-1 | [Synonyms]
2MeSAMP bis-sodium
2 MeS AMP bis-sodium
2-MeS-AMP bis-sodium | [Molecular Formula]
C11H17N5NaO7PS | [MOL File]
81921-45-1.mol | [Molecular Weight]
417.31 |
| Hazard Information | Back Directory | [Uses]
2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation[1][2][3]. | [References]
[1] John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. DOI:10.1124/jpet.114.215616
[2] Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. DOI:10.1161/ATVBAHA.110.213702
[3] A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22. DOI:10.1358/mf.2006.28.5.990205 |
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