| Identification | Back Directory | [Name]
3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE | [CAS]
100202-39-9 | [Synonyms]
Methyl azetidine-3-carbox...
methyl azetidine-3-carboxylate HCl
Methyl 3-Azetidine carboxylate HCl
AZETIDINE-3-CARBOXYLIC METHYL ESTER HCL
3-AZETIDINECARBOXYLIC ACID, MEHYDROCHLORIDE
AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER HCL
Methyl azetidine-3-carboxylate hydrochloride
Azetidine-3-Methyl carboxylate Hydrochloride
MethylAzetidine-3-carboxylateHydrochloride>
Methylazetidine-3-carboxylatehydrochloride,95%
Azetidine-3-carboxylic methyl ester hrdrochloride
AZETIDINE-3-CARBOXYLIC METHYL ESTER HYDROCHLORIDE
Azetidine-3-Carboxylic Acid Methyl Ester Hydrochloride
3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
3-Azetidinecarboxylic acid methyl ester hydrochloride ,95%
3-Azetidinecarboxylic acid, Methyl ester, hydrochloride (1:1)
3-Azetidinecarboxylic acid, methyl ester, hydrochloride (1:1) CAS_EXAMPLE | [EINECS(EC#)]
815-099-3 | [Molecular Formula]
C5H10ClNO2 | [MDL Number]
MFCD01861758 | [MOL File]
100202-39-9.mol | [Molecular Weight]
151.59 |
| Chemical Properties | Back Directory | [Melting point ]
93.0 to 97.0 °C | [Boiling point ]
187-192℃ | [Fp ]
69°(156°F) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [Water Solubility ]
Soluble in water | [form ]
powder to crystal | [color ]
White to Almost white | [InChI]
InChI=1S/C5H9NO2.ClH/c1-8-5(7)4-2-6-3-4;/h4,6H,2-3H2,1H3;1H | [InChIKey]
UOCWTLBPYROHEF-UHFFFAOYSA-N | [SMILES]
C(C1CNC1)(=O)OC.Cl |
| Hazard Information | Back Directory | [Uses]
Methyl Azetidine-3-carboxylate Hydrochloride can be used to prepare inhibitors of of human glycogen phosphorylase to treat hyperglycemia, hyperinsulinemia, hyperlipidemia, insulin resistance or tissue ischemia. | [Synthesis]
The general procedure for the synthesis of methyl azetidine-3-carboxylate hydrochloride from methyl 1 -diphenylmethylazetidine-3-carboxylate was as follows (Preparative Example 85): methyl 1 -diphenylmethylazetidine-3-carboxylate (3.57 g) was dissolved in methanol (360 ml), and ethyl acetate solution of 4N hydrochloric acid (12.7 ml) was added, and the reaction system was maintained at 20 °C. Subsequently, palladium hydroxide (3.57 g) was added as a catalyst and the reaction was stirred at room temperature and under pressurized hydrogen atmosphere (0.4 MPa) for 11 hours. After completion of the reaction, the catalyst was removed by filtration and washed with methanol and water. The filtrate was concentrated to give the crude product of methyl azetidine-3-carboxylate hydrochloride, which presented as a light yellow oil. The reaction was assessed to be quantitative and 1.93 g of product was obtained, which can be used directly in subsequent reactions. The product was detected by ESI-MS, m/z: 116 [M + H]+. | [IC 50]
Non-cleavable Linker | [References]
[1] Patent: EP1889836, 2008, A1. Location in patent: Page/Page column 80
[2] Patent: US2008/214815, 2008, A1. Location in patent: Page/Page column 14-15 |
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