| Identification | More | [Name]
BENZYL 1-PIPERAZINECARBOXYLATE | [CAS]
31166-44-6 | [Synonyms]
1-(BENZYLOXYCARBONYL)PIPERAZINE
1-Z-PIPERAZINE
BENZYL 1-PIPERAZINECARBOXYLATE
BENZYL PIPERAZINE-1-CARBOXYLATE
LABOTEST-BB LT00138040
N-CBZ-PIPERAZINE
PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER
1-Cbz-Piperazine
1-carbobenzoxypiperazine
1-(Benzyloxycarbonyl)piperazine, 1-Cbz-Piperazine, Benzyl piperazine-1-carboxylate | [EINECS(EC#)]
629-513-3 | [Molecular Formula]
C12H16N2O2 | [MDL Number]
MFCD00274317 | [Molecular Weight]
220.27 | [MOL File]
31166-44-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to yellowish liquid | [Boiling point ]
158-161 °C1.4 mm Hg(lit.)
| [density ]
1.142 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.546(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Sparingly), Methanol (Sparingly) | [form ]
Oil | [pka]
8.44±0.10(Predicted) | [color ]
Clear Colourless to Pale Yellow | [BRN ]
179500 | [InChI]
InChI=1S/C12H16N2O2/c15-12(14-8-6-13-7-9-14)16-10-11-4-2-1-3-5-11/h1-5,13H,6-10H2 | [InChIKey]
CTOUWUYDDUSBQE-UHFFFAOYSA-N | [SMILES]
N1(C(OCC2=CC=CC=C2)=O)CCNCC1 | [CAS DataBase Reference]
31166-44-6(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-23 | [HS Code ]
29335990 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellowish liquid | [Uses]
1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter. | [Synthesis]
30.16 g (0.1536 mol) of piperazine hexahydrate was placed in an ice bath with 150 mL of water and 185 mL of tert-butanol.
in an ice bath, cooled to 5° C. 24.4 mL of 2.5 N sodium hydroxide was added dropwise, followed by the slow dropwise addition of 1 |
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