| Identification | Back Directory | [Name]
4-Quinazolinamine, N-cyclohexyl-2-cyclopropyl- | [CAS]
1002801-51-5 | [Synonyms]
4-Quinazolinamine, N-cyclohexyl-2-cyclopropyl- | [Molecular Formula]
C17H21N3 | [MOL File]
1002801-51-5.mol | [Molecular Weight]
267.37 |
| Chemical Properties | Back Directory | [Boiling point ]
382.2±30.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Solid | [pka]
6.96±0.50(Predicted) | [color ]
White to off-white | [InChIKey]
ZQMGQZOHIDOPCQ-UHFFFAOYSA-N | [SMILES]
C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1 |
| Hazard Information | Back Directory | [Uses]
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. | [Biological Activity]
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
TH10785 (6.25 μM, 30 min) induces a de novo β, δ-elimination in vitro, allowing for AP sites as new substrates.TH10785 (10 μM, 0-2 min) allows OGG1 to increase DNA repair by addressing AP sites.TH10785 (0-20 μM, 72 h) induces OGG1 β, δ-lyase activity shifts cells toward PNKP1 dependence.TH10785 (2 μM) has affinity to OGG1 (KD=5.5 μM) increased when adding an AP site analog containing double-stranded DNA (KD=1.3 μM)[1]. | [storage]
Store at -20°C | [References]
[1]. Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376(6600):1471-1476. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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