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1005264-47-0

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1005264-47-0 Structure

1005264-47-0 Structure
IdentificationBack Directory
[Name]

MX-69
[CAS]

1005264-47-0
[Synonyms]

MX-69
CS-2402
MX69 (MX 69
Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-
[Molecular Formula]

C27H26N2O4S
[MOL File]

1005264-47-0.mol
[Molecular Weight]

474.57
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Uses]

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
[in vivo]

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].

[References]

[1] Lubing Gu, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636 DOI:10.1016/j.ccell.2016.08.015
[2] Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636
Spectrum DetailBack Directory
[Spectrum Detail]

MX-69(1005264-47-0)1HNMR
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