| Identification | Back Directory | [Name]
CVT-10216 | [CAS]
1005334-57-5 | [Synonyms]
CS-1424
CVT-10216
GS 455534
CVT-10216;CVT 10216;CVT10216
3-(((3-(4-(Methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)oxy)methyl)benzoic acid
3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic acid
3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]-benzoic acid
Benzoic acid, 3-[[[3-[4-[(methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]- | [Molecular Formula]
C24H19NO7S | [MDL Number]
MFCD18072197 | [MOL File]
1005334-57-5.mol | [Molecular Weight]
465.48 |
| Chemical Properties | Back Directory | [Boiling point ]
714.2±70.0 °C(Predicted) | [density ]
1.468±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH | [form ]
Powder | [pka]
4.13±0.10(Predicted) | [color ]
White to off-white | [InChI]
1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28) | [InChIKey]
YYOOFJZTRCPVFD-UHFFFAOYSA-N | [SMILES]
O=C(O)C1=CC(COC2=CC=C3C(OC=C(C4=CC=C(NS(C)(=O)=O)C=C4)C3=O)=C2)=CC=C1 |
| Hazard Information | Back Directory | [Uses]
3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-chromen-7-yl]oxy]methyl]benzoic Acid is a highly selective reversible aldehyde dehydrogenase 2 (ALDH-2) inhibitor that reduce alcohol and cocaine intake in rats. It also has anxiolytic properties as well as reduces excessive alcohol drinking. | [Biological Activity]
CVT-10216 is a selective reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), thereby inhibiting dopamine synthesis. CVT-10216 is active in suppressing alcohol and cocaine use, and anxiety.', 'CVT-10216 possesses unequivocal anxiolytic properties. It will not affect the suppression of locomotor activity by mCPP (m-chlorophenylpiperazine). | [in vivo]
CVT-10216 (intraperitoneal?injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1].
CVT-10216 (intraperitoneal?injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1]. | [IC 50]
ALDH2 | [storage]
Store at +4°C |
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D&C Chemicals
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