| Identification | Back Directory | [Name]
Benzamide, 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]- | [CAS]
1005784-60-0 | [Synonyms]
CLK1/2IN3
CLK1/2-IN-3
CLK1/2 IN 3
CLK1/2 inhibitor 3
CLK1/2-inhibitor-3
Benzamide, 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl]- | [Molecular Formula]
C21H21N5O2 | [MOL File]
1005784-60-0.mol | [Molecular Weight]
375.42 |
| Hazard Information | Back Directory | [Description]
CLK1/2-IN-3 is a selective CLK1 and CLK2 inhibitor. | [Uses]
LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1]. | [IC 50]
CLK1: 1.1 nM (IC50); CLK2: 2.1 nM (IC50); SRPK1: 130 nM (IC50); SRPK2: 260 nM (IC50); SRPK3: 260 nM (IC50) | [References]
[1] Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10(1):e0116929. Published 2015 Jan 12. DOI:10.1371/journal.pone.0116929 |
|
|