| Identification | Back Directory | [Name]
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid | [CAS]
1006699-45-1 | [Synonyms]
PIM-IN-2
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid | [Molecular Formula]
C19H22N4O2 | [MOL File]
1006699-45-1.mol | [Molecular Weight]
338.4 |
| Chemical Properties | Back Directory | [Boiling point ]
592.7±50.0 °C(Predicted) | [density ]
1.231±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
4.24±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1]. | [IC 50]
PIM2 | [References]
[1] Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827. DOI:10.1021/jm801242y |
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