| Identification | Back Directory | [Name]
3,4-diMethoxy-N-(4-(3-nitrophenyl)-5-(piperidin-1-ylMethyl)thiazol-2-yl)benzenesulfonaMide | [CAS]
1008119-83-2 | [Synonyms]
JM 6
JM 6 (enzyme inhibitor)
JM6
(KMO inhibitor JM6)
2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole
3,4-diMethoxy-N-(4-(3-nitrophenyl)-5-(piperidin-1-ylMethyl)thiazol-2-yl)benzenesulfonaMide
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide
Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-
3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(piperidin-1-ylmethyl)-1,3-thiazol-2-yl]benzenesulfonamide | [Molecular Formula]
C23H26N4O6S2 | [MDL Number]
MFCD22380618 | [MOL File]
1008119-83-2.mol | [Molecular Weight]
518.61 |
| Chemical Properties | Back Directory | [Boiling point ]
692.2±65.0 °C(Predicted) | [density ]
1.391±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble2mg/mL (clear solution, warmed) | [form ]
powder | [pka]
5.90±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide is also known as JM6. Studies have shown JM6 participates in the inhibitory effects towards kynurenine 3-mono
oxygenase in its activities in blood ameliorates neurodegeneration. | [Uses]
3,4-dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide is also known as JM6. Studies have shown JM6 participates in the inhibitory effects towards kynurenine 3-monooxygenase in its activities in blood ameliorates neurodegeneration. | [Biological Activity]
JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) th at increases kynurenic acid levels and reduces extracellular glutamate in the brain. JM6 prevents spatial memory deficitsanxiety-related behaviorand synaptic loss in mouse model of Alzheimer disease. |
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ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878 |
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https://www.chemicalbook.com/ShowSupplierProductsList15061/0.htm |
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SPIRO PHARMA
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www.spiropharma.com.cn |
| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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