| Identification | More | [Name]
4-Acetamidophenylboronic acid | [CAS]
101251-09-6 | [Synonyms]
4-ACETAMIDBENZENEBORONIC ACID
4-ACETAMIDOBENZENEBORONIC ACID
4-ACETAMIDOPHENYLBORONIC ACID
4-ACETAMINOPHENYLBORONIC ACID
4-ACETYLAMINOPHENYLBORONIC ACID
P-ACETAMIDOPHENYLBORONIC ACID
TIMTEC-BB SBB000202
4-Acetamidophenylboronic acid, 97+% | [Molecular Formula]
C8H10BNO3 | [MDL Number]
MFCD02179451 | [Molecular Weight]
178.98 | [MOL File]
101251-09-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light yellow crystal powde | [Melting point ]
215-220 °C (lit.) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator (+4°C) | [form ]
Powder | [pka]
8.63±0.10(Predicted) | [color ]
Gray-tan | [Water Solubility ]
85 g/L (70 ºC) | [InChI]
1S/C8H10BNO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5,12-13H,1H3,(H,10,11) | [InChIKey]
VYEWTHXZHHATTA-UHFFFAOYSA-N | [SMILES]
CC(=O)Nc1ccc(cc1)B(O)O | [CAS DataBase Reference]
101251-09-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29319090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow crystal powde | [Uses]
Reactant involved in:
- Synthesis of TpI2 kinase inhibitors
- Biological evaluation of modulators of survival motor neuron protein
- Cross-coupling with conjugated dienes or terminal alkenes or diazoesters
- Synthesis of tetrabutylammonium trifluoroborates
- Rhosium-catalyzed cyanation
| [Synthesis]
To a three-neck flask was added 13.7 g (0.1 mol) of 4-aminophenylboronic acid and 100 mL of trichloromethane. After thorough stirring, the reaction mixture was cooled to 5 °C and then 23.4 g (0.3 mol) of acetyl chloride was added slowly dropwise. After maintaining the reaction temperature at 5°C to complete the dropwise addition, the reaction system was warmed to 40°C and the reaction continued to be stirred for 3 hours. Upon completion of the reaction, 150 mL of water was added to the reaction mixture and the resulting solid product was washed with stirring. Subsequently, the solid was separated by filtration and washed with an appropriate amount of cold water. Finally, the resulting solid was dried in a vacuum drying oven to obtain 14 g of white or off-white solid powder 4-acetylaminophenylboronic acid in 78.2% yield. | [References]
[1] Patent: CN106946920, 2017, A. Location in patent: Paragraph 0017; 0018; 0020 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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Adamas Reagent, Ltd.
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4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
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