| Identification | More | [Name]
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate | [CAS]
101385-69-7 | [Synonyms]
2-CHLORO-1,3-DIMETHYL-2-IMIDAZOLINIUM HEXAFLUOROPHOSPHATE
2-CHLORO-1,3-DIMETHYLIMIDAZOLIDINIUM HEXAFLUOROPHOSPHATE
2-CHLORO-1,3-DIMETHYLIMIDAZOLINIUM HEXAFLUOROPHOSPHATE
2-CHLORO-1,3-DIMETHYLIMIDAZOLINIUM PF6
CIP
2-Chlor-1,3-dimethyl-imidazolidinium-hexafluorophosphat
2-CHLORO-1,3-DIMETHYLIMIDAZOLINIUM HEXAFLUOROPHOSPHATE 98+% | [EINECS(EC#)]
628-484-4 | [Molecular Formula]
C5H12ClF6N2P | [MDL Number]
MFCD00191914 | [Molecular Weight]
280.58 | [MOL File]
101385-69-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
231-233 °C (lit.) | [storage temp. ]
2-8°C
| [solubility ]
acetonitrile: 0.1 g/mL, clear
| [form ]
powder to crystal | [color ]
White to Almost white | [Sensitive ]
Moisture & Light Sensitive | [BRN ]
5369058 | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C5H10ClN2.F6P/c1-7-3-4-8(2)5(7)6;1-7(2,3,4,5)6/h3-4H2,1-2H3;/q+1;-1 | [InChIKey]
CNAKHAGVVMOXFE-UHFFFAOYSA-N | [SMILES]
[P-](F)(F)(F)(F)(F)F.C1(Cl)=[N+](C)CCN1C | [CAS DataBase Reference]
101385-69-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
8-10-21 | [HS Code ]
29332900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder | [Uses]
Reactant for synthesis of:
Diazo-transfer reagents
Reagent for synthesis of:
Cannabinoid CB1 receptor agonists
Selective small-molecule melanocortin-4 receptor agonists
Imidazoles as selective cannabinoid CB2 receptor antagonists
Cyclic alpha-peptoids
Cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor | [General Description]
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate is a reagent used for the coupling and esterification of sterically hindered amino acids.[1] | [reaction suitability]
reaction type: Coupling Reactions | [Solubility in organics]
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate is soluble in DMF; partially soluble in H2O, MeOH, EtOAc, CH2Cl2, and CHCl3. | [storage]
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate (CIP) can be stored refrigerated for at least 5 years without loss of reactivity. CIP is an irritant and should be used in a fumehood, when possible. | [References]
1. (a) Humphery, J. M.; Chamberlin, R., Chem. Rev. 1997, 97, 2243. (b) Albericio, F.; Carpino, L. A., Methods Enzymol. 1997, 289, 104 |
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