| Identification | Back Directory | [Name]
X-082 | [CAS]
1013920-15-4 | [Synonyms]
X82
X-82
X 82
X-082
CM082
CM-082
CM 082
Vorolanib
1H-Pyrrole-3-carboxamide, N-[(3S)-1-[(dimethylamino)carbonyl]-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- | [Molecular Formula]
C23H26FN5O3 | [MOL File]
1013920-15-4.mol | [Molecular Weight]
439.48 |
| Chemical Properties | Back Directory | [Boiling point ]
657.8±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 27 mg/mL (61.44 mM) | [form ]
Solid | [pka]
11.70±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Vorolanib is an oral anti-VEGFR/PDGFR/CSF1R tyrosine kinase inhibitor that can inhibit angiogenesis in vitro and in vivo. | [in vivo]
Vorolanib (CM082; 20 mg/kg; gavage; once every 2 days; 1 h before SKF 104864A; for 23 days) enhances the anti-tumor effect of SKF 104864A on xenografts of ABCG2-overexpressing cells[1].
?
Vorolanib (80 mg/kg; twice daily; for 21 days) has antitumor activity combined with ZD1839 (10 mg/kg; q.d; for 21 days) on H3255 tumor xenograft (female BALB/c nude mice aged five weeks)[2].
| [storage]
Store at -20°C |
|
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 19945035818 |
| Website: |
www.topule.com/ |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|