| Identification | More | [Name]
OLOMOUCINE | [CAS]
101622-51-9 | [Synonyms]
OLOMOUCINE
NSC 666096
Olomoucine,highpurity
OLOMOUCINE SYNTHETIC >95%
Olomoucine,98%,high purity
N2-[(2-HYDROXYETHYL)]-N6-BENZYLADENINE
Olomoucine - CAS 101622-51-9 - Calbiochem
2-(hydroxyethylamino)-6-benzylamino-9-methylpurine
6-BENYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-METHYLPURINE
2-(2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-METHYLPURINE
2-(2'-Hydroxyethylamino)-9-methyl-6-(benzylamino)purine
2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol
2-[[9-Methyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol
2-[(2-Hydroxyethyl)amino]-6-benzylamino-9-methyl-9H-purine
N-(2-Hydroxyethyl)-N'-benzyl-9-methyl-9H-purine-2,6-diamine
Olomoucine6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
2-[[9-METHYL-6[(PHENYLMETHYL)AMINO]-9H-PURIN-2-YL]AMINO]-ETHANOL
Ethanol, 2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine | [Molecular Formula]
C15H18N6O | [MDL Number]
MFCD00189360 | [Molecular Weight]
298.34 | [MOL File]
101622-51-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white solid | [Melting point ]
120-130 °C | [Boiling point ]
579.6±60.0 °C(Predicted) | [density ]
1.36 | [storage temp. ]
−20°C
| [solubility ]
DMSO, Methanol (Slightly) | [form ]
Solid | [pka]
14.55±0.10(Predicted) | [color ]
White to off-white | [Usage]
A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest | [CAS DataBase Reference]
101622-51-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white solid | [Uses]
A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest | [Uses]
A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. | [Definition]
ChEBI:Olomoucine is a 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a member of 2,6-diaminopurines and a member of ethanolamines. | [Biological Activity]
Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M)? and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase. | [Biochem/physiol Actions]
Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest. | [Enzyme inhibitor]
This ATP site-competitive purine derivative (FW = 298.35 g/mol; CAS 101622-51-9), systematically named 6-benzylamino-2-[2-hydroxyethylamino]- 9-methylpurine, is a potent inhibitor of cyclin-dependent kinases, with an IC50 value of 7 μM for both cdk1 and cdk2 and an IC50 value of 3 μM for cdk5, arresting cells in G1. Olomoucine also inhibits cytokinin 7b-glucosyltransferase. | [storage]
Store at -20°C | [References]
[1]. vesel j, havlicek l, strnad m, et al. inhibition of cyclin-dependent kinases by purine analogues. eur j biochem. 1994 sep 1;224(2):771-86.
[2]. abraham rt, acquarone m, andersen a, et al. cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. biol cell. 1995;83(2-3):105-20.
[3]. tian ds, xie mj, yu zy, et al. cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. brain res. 2007 mar 2;1135(1):177-85. |
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