| Identification | Back Directory | [Name]
cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate | [CAS]
1018673-42-1 | [Synonyms]
CHR5154
CS-2598
CS-2158
CHR-5154
HDAC-IN-3
GSK3117391
GSK3117391A
HDAC inhibitor 3
CHR-5154; CHR5154
GSK 3117391;GSK-3117391
cyclopentyl 2-cyclohexyl-2-((6-(3-(hydroxyamino)-3-oxopropyl)pyridin-3-yl)methylamino)acetate
Cyclohexyl-{[6-(2-hydroxycarbamoyl-ethyl)-pyridin-3-ylmethyl]-amino}-acetic acid cyclopentyl ester
Cyclohexaneaceticacid,α-[[[6-[3-(hydroxyamino)-3-oxopropyl]-3-pyridinyl]methyl]amino]-,cyclopentylester,(αS)-
Cyclohexaneacetic acid, α-[[[6-[3-(hydroxyamino)-3-oxopropyl]-3-pyridinyl]methyl]amino]-, cyclopentyl ester, (αS)- | [EINECS(EC#)]
827-399-1 | [Molecular Formula]
C22H33N3O4 | [MDL Number]
MFCD29924725 | [MOL File]
1018673-42-1.mol | [Molecular Weight]
403.52 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:81.0(Max Conc. mg/mL);200.73(Max Conc. mM)
Ethanol:15.0(Max Conc. mg/mL);37.17(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Description]
GSK3117391 is a histone deacetylase (HDAC) inhibitor (IC50 = <100 nM in HeLa nuclear extracts). It inhibits growth of U937 and HUT cancer cells (IC50s = <330 nM). | [Uses]
GSK3117391 (ESM-HDAC391) is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1.
Target: HDAC | [IC 50]
HDAC | [References]
[1] Davidson Alan Hornsby, et al. Preparation of amino acid-based hydroxamic acids as histone deacetylase (HDAC) inhibitors. From PCT Int. Appl. (2008), WO 2008040934 A1 20080410. |
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