| Identification | Back Directory | [Name]
GSK-2881078 | [CAS]
1539314-06-1 | [Synonyms]
CS-2336
GSK-2881078
SARM GS2881078
GSK2881078; GSK 2881078
GSK-2881078 (Free base)
1-[(2R)-1-(Methylsulfonyl)-2-propanyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile
1H-Indole-5-carbonitrile, 1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethyl)- | [EINECS(EC#)]
1539314-060-1 | [Molecular Formula]
C14H13F3N2O2S | [MDL Number]
MFCD30343844 | [MOL File]
1539314-06-1.mol | [Molecular Weight]
330.33 |
| Chemical Properties | Back Directory | [Boiling point ]
521.6±50.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | [form ]
crystalline solid | [color ]
White to off-white | [InChI]
InChI=1S/C14H13F3N2O2S/c1-9(8-22(2,20)21)19-6-5-11-12(19)4-3-10(7-18)13(11)14(15,16)17/h3-6,9H,8H2,1-2H3/t9-/m1/s1 | [InChIKey]
SKDVMPZQJMZEAC-SECBINFHSA-N | [SMILES]
N1([C@H](C)CS(C)(=O)=O)C2=C(C(C(F)(F)F)=C(C#N)C=C2)C=C1 |
| Hazard Information | Back Directory | [Description]
GSK2881078 is a selective androgen receptor modulator (SARM).1 It induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM), an effect that can be inhibited by the non-steroidal AR antagonist bicalutamide (Item No. 14250). | [Uses]
GSK 2881078 is a selective androgen receptor modulator which can display agonistic properties in anabolic target tissues | [References]
[1]. https://newdrugapprovals.org/2016/06/14/gsk-2881078/ |
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