| Identification | Back Directory | [Name]
Tie-2 Inhibitor 7 | [CAS]
1020412-97-8 | [Synonyms]
Tie2 inhibitor
Tie inhibitor 7
Tie-2 Inhibitor 7
TIE2 INHIBITOR;TIE INHIBITOR 7
Tie2 Inhibitor 7,Tie-2 Inhibitor 7
(S)-5-(4-(((2-((1-Cyclohexylethyl)amino)-2-oxoethyl)((p-tolyloxy)carbonyl)amino)methyl)phenyl)nicotinic acid
3-Pyridinecarboxylic acid, 5-[4-[[[2-[[(1S)-1-cyclohexylethyl]amino]-2-oxoethyl][(4-methylphenoxy)carbonyl]amino]methyl]phenyl]- | [Molecular Formula]
C31H35N3O5 | [MDL Number]
MFCD28138125 | [MOL File]
1020412-97-8.mol | [Molecular Weight]
529.63 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 14 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. |
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