| Identification | Back Directory | [Name]
4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide | [CAS]
870223-96-4 | [Synonyms]
AMG-Tie2
AMG-Tie2-1
PubChem22413
4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b
4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide
4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413 | [Molecular Formula]
C25H20F3N5O2 | [MDL Number]
MFCD16038641 | [MOL File]
870223-96-4.mol | [Molecular Weight]
479.45 |
| Chemical Properties | Back Directory | [density ]
1.357 | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC50 = 10 nM). | [Uses]
AMG-Tie 2-1 is a pyridinyltriazine Tie-2 kinase inhibitor. A useful research chemical for cancer metabolism research studies. | [storage]
Store at -20°C |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
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| Website: |
www.spiropharma.com.cn |
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