| Identification | More | [Name]
3-(4-Nitrophenyl)-beta-alanine | [CAS]
102308-62-3 | [Synonyms]
3-AMINO-3-(4-NITROPHENYL)PROPANOIC ACID
3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
3-(P-NITROPHENYL)-DL-BETA-ALANINE
DL-3-AMINO-3-(4-NITRO-PHENYL)-PROPIONIC ACID
RARECHEM AK HD C007
3-(4-Nitrophenyl)-beta-alanine | [Molecular Formula]
C9H10N2O4 | [MDL Number]
MFCD00187210 | [Molecular Weight]
210.19 | [MOL File]
102308-62-3.mol |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-amino-3-(4-nitrophenyl)propionic acid from malonic acid and p-nitrobenzaldehyde: A mixture of 2.40 g of p-nitrobenzaldehyde, 2.44 g of malonic acid, and 3.54 g of ammonium acetate (molar ratio 1:1.1:2.3) was dissolved in 200 mL of 1 -butanol, and the reaction was carried out at reflux for 1.5-2 hr until the release of carbon dioxide gas stopped. Upon completion of the reaction, the precipitate formed was filtered and washed sequentially with boiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and 100 mL of water. The precipitate was dried at 80-100°C for 8-10 hours. The purity of the product was checked by thin layer chromatography (TLC) and the reaction yield was about 65-80%. | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268 |
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