| Identification | Back Directory | [Name]
BAY 60-2770
(BAY 602770) | [CAS]
1027642-43-8 | [Synonyms]
BAY 60-2770
BAY 60-2770 >=98% (HPLC)
BAY 60-2770
(BAY 602770)
Benzoic acid, 4-?[[(4-?carboxybutyl)?[2-?[5-?fluoro-?2-?[[4'-?(trifluoromethyl)?[1,?1'-?biphenyl]?-?4-?yl]?methoxy]?phenyl]?ethyl]?amino]?methyl]?- | [Molecular Formula]
C35H33F4NO5 | [MDL Number]
MFCD32174336 | [MOL File]
1027642-43-8.mol | [Molecular Weight]
623.63 |
| Chemical Properties | Back Directory | [Boiling point ]
733.5±60.0 °C(Predicted) | [density ]
1.288±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
4.02±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2]. | [Biological Activity]
BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2].
BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1].BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2]. | [in vivo]
BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1].
BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2]. | Animal Model: | Obese mice[2] | | Dosage: | 1 mg/kg | | Administration: | p.o.; daily from the 10th to the 12th week | | Result: | Ameliorates detrusor dysfunction in obese mice.
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| [References]
[1]. Knorr A, et al. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis. Arzneimittelforschung. 2008;58(2):71-80.[2]. Leiria LO, et al. The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice. J Urol. 2014 Feb;191(2):539-47. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|