| Identification | More | [Name]
N-METHYLISATOIC ANHYDRIDE | [CAS]
10328-92-4 | [Synonyms]
AKOS 226
MIA
N-METHYLISATOIC ANHYDRIDE
TIMTEC-BB SBB000196
1-Methyl-2H-3,1-benzoxazine-2,4(1H)-dione
2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-
4(1h)-dione,1-methyl-2h-1-benzoxazine-2
N-Methyl ia
n-methylia
N-Methyl-N-carboxyanthranilic anhydride
N-METHYLISATOIC ANHYDRIDE, TECH., 90%
N-Methylisatoicanhydride,tech.,90%
1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
1-Methyl-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione
1-Methyl-1H-3,1-benzoxazine-2,4-dione
1-Methyl-4H-3,1-benzoxazine-2(1H),4-dione | [EINECS(EC#)]
233-714-8 | [Molecular Formula]
C9H7NO3 | [MDL Number]
MFCD00006815 | [Molecular Weight]
177.16 | [MOL File]
10328-92-4.mol |
| Chemical Properties | Back Directory | [Appearance]
brownish chunks | [Melting point ]
165 °C (dec.)(lit.) | [Boiling point ]
309.06°C (rough estimate) | [density ]
1.3312 (rough estimate) | [vapor density ]
6.1 (vs air)
| [refractive index ]
1.5200 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-2.24±0.20(Predicted) | [color ]
White to yellow | [Sensitive ]
Moisture Sensitive | [InChI]
InChI=1S/C9H7NO3/c1-10-7-5-3-2-4-6(7)8(11)13-9(10)12/h2-5H,1H3 | [InChIKey]
KJMRWDHBVCNLTQ-UHFFFAOYSA-N | [SMILES]
N1(C)C2=CC=CC=C2C(=O)OC1=O | [CAS DataBase Reference]
10328-92-4(CAS DataBase Reference) | [EPA Substance Registry System]
2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl- (10328-92-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
DM3140000
| [TSCA ]
Yes | [HS Code ]
2934.99.4400 |
| Hazard Information | Back Directory | [Chemical Properties]
brownish chunks | [Uses]
N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs, and is widely used for resolving secondary RNA structures using the SHAPE (Selective 2'-Hydroxyl Acylation Analyzed by Primer Extension) technology. | [Application]
N-Methylisatoic anhydride was first condensed with ethanolamine to give N-(2-hydroxyethyl)-2-methylaminobenzamide. Cyclization of the latter with ethyl pyruvate gave quinazoline derivatives which, upon hydrolysis and dehydrative cyclization with l-methyl-2-chloropyridinium iodide, afforded the l,4-oxazines[3,4-]quinazoline. | [Definition]
ChEBI: A 3,1-benzoxazin-1,4-dione having an N-methyl substituent. | [storage]
Store at -20°C |
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