| Identification | Back Directory | [Name]
AZD5423 | [CAS]
1034148-04-3 | [Synonyms]
AZD5423
AZD 5423;AZD-5423
AZD 5423,AZD5423,Inhibitor,Glucocorticoid Receptor,inhibit,AZD-5423
2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide
Acetamide, 2,2,2-trifluoro-N-[(1S,2R)-2-[[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy]-2-(3-methoxyphenyl)-1-methylethyl]- | [Molecular Formula]
C25H21F4N3O3 | [MOL File]
1034148-04-3.mol | [Molecular Weight]
487.45 |
| Chemical Properties | Back Directory | [Boiling point ]
573.8±50.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (205.15 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.39±0.46(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2]. | [storage]
Store at -20°C | [References]
[1] Werkstr?m V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. DOI:10.1111/bcpt.12621
[2] Gauvreau GM, et al. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. DOI:10.1164/rccm.201404-0623OC |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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