| Identification | Back Directory | [Name]
1H-Imidazolium, 1,3-bis[2-(3,4-dichlorophenyl)-2-oxoethyl]-, bromide (1:1) | [CAS]
1037732-88-9 | [Synonyms]
VUF10132
VUF-10132
VUF 10132
1H-Imidazolium, 1,3-bis[2-(3,4-dichlorophenyl)-2-oxoethyl]-, bromide (1:1) | [Molecular Formula]
C19H13BrCl4N2O2 | [MOL File]
1037732-88-9.mol | [Molecular Weight]
523.03 |
| Hazard Information | Back Directory | [Description]
VUF10132 is a full inverse agonist at CXCR3 N3.35A. | [Uses]
VUF10132 is a non-peptide CXCR3 receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor[1]. | [References]
[1] Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors |
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