| Identification | Back Directory | [Name]
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- | [CAS]
1037826-43-9 | [Synonyms]
A933548
A-933548
A 933548
3-Pyridinecarboxamide, N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-2-(3-phenyl-1H-pyrazol-1-yl)- | [Molecular Formula]
C25H21N5O3 | [MOL File]
1037826-43-9.mol | [Molecular Weight]
439.47 |
| Hazard Information | Back Directory | [Description]
A-933548 is a potent Calpain inhibitor for the Treatment of Alzheimer's Disease. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays | [Uses]
A-933548 is a potent and selective inhibitor of calpain, with a Ki of 18 nM. A-933548 can be used for the research of Alzheimer's disease[1]. | [References]
[1] Kling A, et, al. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides. J Med Chem. 2017 Aug 24;60(16):7123-7138. DOI:10.1021/acs.jmedchem.7b00731 |
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