| Identification | Back Directory | [Name]
WAY 361789 | [CAS]
1040718-40-8 | [Synonyms]
WAY 361789
WAY 361789,WAY361789
5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide | [Molecular Formula]
C22H31N5O3 | [MDL Number]
MFCD25976903 | [MOL File]
1040718-40-8.mol | [Molecular Weight]
413.513 |
| Hazard Information | Back Directory | [Uses]
WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC50 of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia[1]. | [IC 50]
AChE | [References]
[1] Zanaletti R, et al. Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). J Med Chem. 2012 May 24;55(10):4806-23. DOI:10.1021/jm300247y |
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