| Identification | Back Directory | [Name]
Spiro[cyclopentane-1,1'(4'H)-naphthalen]-4'-one, 5',8'-dihydroxy- | [CAS]
104260-73-3 | [Synonyms]
Collagen-IN-1
Spiro[cyclopentane-1,1'(4'H)-naphthalen]-4'-one, 5',8'-dihydroxy- | [Molecular Formula]
C14H14O3 | [MOL File]
104260-73-3.mol | [Molecular Weight]
230.26 |
| Hazard Information | Back Directory | [Uses]
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research[1]. | [References]
[1] Diego Méndez, et al. Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Eur J Med Chem. 2020 Apr 15;192:112187. DOI:10.1016/j.ejmech.2020.112187 |
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