| Hazard Information | Back Directory | [Description]
THDP-17 is a novel glutaminase activity inhibitor, showing a partial uncompetitive inhibition in vitro and a significant reduction of ammonia and glutamate production in vivo. | [Uses]
THDP17 is an orally active glutaminase inhibitor. THDP17 decreases ammonia production through glutaminase inhibition[1]. | [References]
[1] Díaz-Herrero MM, et al. THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy. PLoS One. 2014 Oct 17;9(10):e109787. DOI:10.1371/journal.pone.0109787 |
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