| Identification | Back Directory | [Name]
Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-methoxyphenyl)- | [CAS]
104857-29-6 | [Synonyms]
NSC 694621
Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-methoxyphenyl)- | [Molecular Formula]
C13H10N2O2S | [MOL File]
104857-29-6.mol | [Molecular Weight]
258.3 |
| Chemical Properties | Back Directory | [Melting point ]
164-166 °C(Solv: methanol (67-56-1)) | [Boiling point ]
470.6±51.0 °C(Predicted) | [density ]
1.381±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
0.74±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
IC50: 5.71 µM (PCAF/H31-21)[1]. NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 µM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells[1]. NSC 694621 (25 µM; 72 h) exhibits antiproliferative effect to SK-N-SH and HCT116 cells[1]. Cell Proliferation Assay[1] | [Uses]
NSC 694621 is a potent PCAF inhibitor, with an IC50 of 5.71 μM (PCAF/H31-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells[1]. | [References]
[1] Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. DOI:10.1016/j.bmc.2011.01.063 |
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