| Identification | Back Directory | [Name]
AZD 8329 | [CAS]
1048668-70-7 | [Synonyms]
AZD 8329
AZD 8329
(AZD8329)
XWBXJBSVYVJAMZ-UHFFFAOYSA-N
Benzoic acid, 4-[5-(1,1-dimethylethyl)-4-[(tricyclo[3.3.1.13,7]dec-2-ylamino)carbonyl]-1H-pyrazol-1-yl]- | [Molecular Formula]
C25H31N3O3 | [MOL File]
1048668-70-7.mol | [Molecular Weight]
421.53 |
| Chemical Properties | Back Directory | [Boiling point ]
620.5±50.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 62.5 mg/mL (148.27 mM) | [form ]
Solid | [pka]
3.77±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1]. | [storage]
Store at -20°C | [References]
[1] Scott JS, et al. Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47. DOI:10.1021/jm301252n |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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