| Identification | Back Directory | [Name]
11-Dideuterolinoleic acid | [CAS]
1051366-32-5 | [Synonyms]
POL-6326)
Balixafortide TFA salt
Balixafortide
(POL6326
11-Dideuterolinoleic acid
Cyclo[L-alanyl-L-cysteinyl-L-seryl-L-alanyl-D-prolyl-(2S)-2,4-diaminobutanoyl-L-arginyl-L-tyrosyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-histidyl], cyclic (2→9)-disulfide | [Molecular Formula]
C84H118N24O21S2 | [MDL Number]
MFCD34187225 | [MOL File]
1051366-32-5.mol | [Molecular Weight]
1864.11 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);45.33(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);45.33(Max Conc. mM) | [pka]
9.89±0.15(Predicted) | [Water Solubility ]
Water: 100 mg/mL (53.64 mM); | [Sequence]
H-Ala-Cys-Ser-Ala-Pro-Arg-Tyr-Cys-Tyr-Gln-Lys-Pro-Pro-Tyr-His-OH（Disulfide bridges Cys-Cys） |
| Hazard Information | Back Directory | [Uses]
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2]. | [in vivo]
Balixafortide is optimized for favorable mouse absorption, distribution, metabolism and excretion (ADME) properties with balanced plasma protein binding, greater plasma and microsomal stability[1]. | [IC 50]
CXCR4: <10 nM (IC50) | [References]
[1] Zimmermann J, et al. Anti-tumor cell activity and in vitro profile of the next generation CXCR4 antagonist Balixafortide. Ann Oncol. 2018 Oct;29 Suppl 8:viii103.
[2] Karpova D, et al. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial. J Transl Med. 2017 Jan 3;15(1):2. DOI:10.1186/s12967-016-1107-2 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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